DRUG-loaded cylindrical polymer matrices, composed of poly (N-vinyl-2-pyrrolidone) and poly(acrylamide-co-maleic acid) have been synthesized and the release of vitamin B2 from these gels has been studied at the physiological temperature 37°C. The devices show strong pH-dependent release behavelour, thus offering a maximum release at pH 7.4. The initial amount of DRUG loaded into the device and the diameter of the cylindrical samples also affect the release kinetics. With the increase in the maleic acid content inside the device having maximum 43.0 mM, the release rate has been found to increase, whereas further increase in the acid content slows down the release rate. Finally, the release of riboflavin from the devices has been explained onthe basis of the swelling-dependent mechanism